According to Crave’s Destructoid website, Assassin’s Creed IV: Black Flag is going to take 48-49 hours to get total sync.
I asked Ashraf Ismail, director on Assassin’s Creed IV, how long it would take and he told me that “one guy in the office actually did it two weeks ago for the first time. He got a 100% sync, which was mind blowing. This was one of our testers, so imagine he’s a tester who knows the game really well. He’s been working on the game for a year and a half. From zero to a hundred on one build [of the game], it took him 48/49 hours. The thing is, he knew what he was doing is the crazy part.”
This includes all of the side missions and optional quests. (How long you play, multiplayer, is up to you!) Assassin’s Creed IV: Black Flag is set for release October 29.